周树堂

1. 个人简介:

周树堂，男，博士，教授，博士生导师。授予“国家有突出贡献中青年专家”，获“国务院政府特殊津贴”。2002年毕业于加拿大皇后大学，获生物化学与分子生物学博士学位。曾经担任美国杜克大学助理教授，中国科学院动物研究所研究员、研究组长，河南农业大学生命科学院院长。目前担任河南大学植物逆境生物学重点实验室副主任，兼任中国昆虫学会理事，发育与遗传专业委员会副主任，国际交流与合作工作委员会副主任，基因组专业委员会委员等。主要从事昆虫分子生物学和植物保护学研究，主持承担国家自然科学基金重点项目、面上项目、973课题、河南省高校创新团队项目等，研究成果发表在PNAS、PLoS Genetics等国际知名刊物，论文被“Faculty of 1000”推荐，出版著作1部，授权专利3项。曾获美国围产期学会“青年科学家奖”，农业部“全国棉铃虫防治先进个人。

2. 教育经历:

1998–2002    加拿大皇后大学 生物化学与分子生物学  博士

1981-1985     河南农业大学   植物保护              学士

3. 工作经历:

2015-至今  河南大学棉花生物学国家重点实验室 河南大学植物逆境生物学重点实验室 生命科学学院 教授

2010–2015 中国科学院动物研究所       研究员    研究组组长

2005–2010 美国杜克大学               助理教授  助理研究员

2007–2009 河南农业大学生命科学院               院长（兼）

2003–2004 加拿大皇后大学             生物化学系与蛋白质功能中心  博士后

4. 承担项目:

(1)国家基金委重点项目，飞蝗对环境变化生殖适应的内分泌调控机制研究（31630070），2017/01-2021/12

(2)国家基金委面上项目，飞蝗卵子发生的microRNA 调控机制研究（31372258），2014/01–2017/12

(3)国家基金委面上项目，飞蝗性成熟期保幼激素作用的分子机制研究（31172149），2012/01-2015/12

(4) 国家“973” 项目子课题，害虫发育与变态的遗传机制（2012CB114101），2012/01－2016/12

(5)河南省高校科技创新团队支持计划，农业昆虫与害虫防治（16IRTSTHN011）， 2016/01-2017/12

5. 代表性论文:

(1)Wu Z, Guo W, Yang L, He Q, Zhou S*. 2018. Juvenile hormone promotes locust fat body cell polyploidization and vitellogenesis by activating the transcription of Cdk6 and E2f1. Insect Biochem Mol Biol. 102: 1-10. doi: 10.1016/j.ibmb.2018.09.002

(2)Guo W, Wu Z, Yang L, Cai Z, Zhao L, Zhou S*. 2018. Juvenile hormone-dependent Kazal-type serine protease inhibitor Greglin safeguards insect vitellogenesis and egg production. FASEB J. doi: 10.1096/fj.201801068R.

(3)Du M, Liu X, Ma N, Liu X, Wei J, Yin X, Zhou S, Rafaeli A, Song Q, An S*. Calcineurin-mediated Dephosphorylation of Acetyl-coA Carboxylase is Required for Pheromone Biosynthesis Activating Neuropeptide (PBAN)-induced Sex Pheromone Biosynthesis in Helicoverpa armigera. Mol Cell Proteomics. 16(12): 2138-2152.

(4)Luo M, Li D, Wang Z, Guo W, Kang L*, Zhou S*. 2017. Juvenile hormone differentially regulates two Grp78 genes encoding protein chaperones required for insect fat body cell homeostasis and vitellogenesis. J Biol Chem. 292(21): 8823-34.

(5)Wang Z, Yang L, Song J, Kang L*, Zhou S*. 2017. An isoform of Taiman that contains a PRD-repeat motif is indispensable for transducing the vitellogenic juvenile hormone signal in Locusta migratoria. Insect Biochem Mol Biol. 82, 31-40.

(6)Du M, Liu X, Ma N, Liu X, Wei J, Yin X, Zhou S, Ada R, Song Q, An S. 2017. Calcineurin-mediated dephosphorylation of Acetyl-coA Carboxylase is required for pheromone biosynthesis activating neuropeptide (PBAN)-induced sex pheromone Biosynthesis in Helicoverpa armigera. Mol Cell Proteomics. 16(12):2138-2152

(7)Wu Z, Guo W，Xie Y, Zhou S*. 2016. Juvenile hormone activates the transcription of Cell-division-cycle 6 (Cdc6) for polyploidy-dependent insect vitellogenesis and oogenesis. J Biol Chem. 291(10): 5418-27.

(8)Guo W#, Wu Z#, Song J. Jiang F, Deng S, Walker VK, Zhou S*. 2014. Juvenile hormone-receptor complex acts on Mcm4 and Mcm7 to promote polyploidy and vitellogenesis in the migratory locust. PLoS Genetics. 10(10): e1004702. #Co-first authors.

(9)Song J, Wu Z, Wang Z, Deng S, Zhou S*. 2014. Krüppel-homolog 1 mediates juvenile hormone action to promote vitellogenesis and oocyte maturation in the migratory locust. Insect Biochem Mol Biol. 52: 94-101.

(10)Liu L, Zheng H, Jiang F, Guo W, Zhou S*. 2014. Comparative transcriptional analysis of asexual and sexual morphs reveals possible mechanisms in reproductive polyphenism of the cotton aphid. PLoS ONE. 9(6): e99506.

(11)Ren D, Cai Z, Song J, Wu Z, Zhou S*. 2014. dsRNA uptake and persistence account for tissue-dependent susceptibility to RNA interference in the migratory locust, Locusta migratoria. Insect Mol Biol. 23(2): 175–184.

(12)Song J, Guo W, Jiang F, Kang L, Zhou S*. 2013. Argonaute 1 is indispensable for juvenile hormone mediated oogenesis in the migratory locust, Locusta migratoria. Insect Biochem Mol Biol. 43(9): 879-887.

(13)Zhou S*, Nissao E, Jackson IL, Leong W, Dancy L, Cuttitta F, Vujaskovic Z, Sunday ME*. Radiation-induced lung injury is mitigated by blockade of gastrin-releasing peptide. Am J Pathol. 2013. 182(4):1248-1254. (14)Zhou S, Degan S, Potts EN, Foster FM, Sunday ME. 2009. NPAS3 is a trachealess homolog critical for lung development and homeostasis. Proc Natl Acad Sci USA. 106(28), 11691-11696. Recommended by “Faculty of 1000”.

(15)Levesque BM#, Zhou S#, Shan L, Kong Y, Sunday ME. 2007. NPAS1 regulates branching morphogenesis in embryonic lung. Am J Respir Cell Mol Biol. 36(4), 427-434. #Co-first authors.

(16)Zhou S, Tejada M, Wyatt GR, Walker VK. 2006. A DNA-binding protein, tfp1, involved in juvenile hormone-regulated gene expression in Locusta migratoria. Insect Biochem Mol Biol. 36: 724-734.

(17)Zhou S, Webb BA, Eves R, Mak AS. 2006. Effects of tyrosine phosphorylation of cortactin on podosome formation in A7r5 vascular smooth muscle cells. Am J Physiol Cell Physiol. 290, C463-471.

(18)Webb BA, Zhou S, Eves R, Shen L, Jia L, Mak AS. 2006. Phosphorylation of cortactin by p21-activated kinase. Arch Biochem Biophys. 456, 183-193.

(19)Eves R, Webb BA, Zhou S, Mak AS. 2006. Caldesmon is an integral component of podosomes in smooth muscle cells. J Cell Sci. 119, 1691-1702.

(20)Webb BA, Eves R, Crawley SW, Zhou S, Côté GP, Mak AS. 2005. PAK1 induces podosome formation in A7r5 vascular smooth muscle cells in a PAK-interacting exchange factor-dependent manner. Am J Physiol Cell Physiol. 289: C898-907.

(21)Hayward DC, Dhadialla TS, Zhou S, Kuiper MJ, Ball EE, Wyatt GR, Walker VK. 2003. Ligand specificity and developmental expression of RXR and ecdysone receptor in the migratory locust. J Insect Physiol. 49, 1135-1144.

(22)Zhou S, Zhang J, Hirai M, Chinzei Y, Kayser H, Wyatt GR, Walker VK. 2002. A DNA-binding protein involved in gene regulation by juvenile hormone. Mol Cell Endocrinol. 190, 177-185.

(23)Zhou S, Zhang J, Fam MD, Wyatt GR, Walker VK. 2002. Sequences of elongation factors-1 and -1 and stimulation by juvenile hormone in Locusta migratoria. Insect Biochem Mol Biol. 32, 1567-1576.